Author Login IJIRT Partner Network (IPN) Login

FORMULATION AND EVALUATION OF PRESS-COATED PULSATILE DELIVERY OF FLURBIPROFEN TABLETS

  • Unique Paper ID: 152644
  • Volume: 8
  • Issue: 3
  • PageNo: 1021-1025
  • Abstract:
  • The objective of present study is to formulate and evaluation of press-coated pulsatile delivery of flurbiprofen tablets for treatment of rheumatoid arthritis. The press coated method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 4 hours. The design of the system consists of a rapid release core and controlled release coat. A combination of HPMC K 15M and eudragit RL 100, was used as a coating material for the tablet. The formulations (F1-F3) of the core were prepared by using crospovidone (CP) as disintegrants in different proportions (10%, 15% and 20%) to study the effect of variable concentrations of these on the characteristics of the formulation. Among these formulations, F1 containing CP (20%) as disintegrant showed a better drug release of 98% over 1hr was selected. The core was coated with of HPMC K 15M and eudragit RL100 with different polymer ratios (F1- F6). Among these, F6 was optimized formulation based on the lag time and percent of drug release (96% of drug release in 6 hours). Thus, compression coated tablets with a clear lag time before drug release is a potentially useful formulation for the treatment of rheumatoid arthritis.
email to a friend

Cite This Article

  • ISSN: 2349-6002
  • Volume: 8
  • Issue: 3
  • PageNo: 1021-1025

FORMULATION AND EVALUATION OF PRESS-COATED PULSATILE DELIVERY OF FLURBIPROFEN TABLETS

Related Articles

09 Apr, 2024

Formulation development, in vitro and in vivo studies of eprosartan mesylate loaded solid lipid nanoparticles for improved bioavailability

Read More
02 Apr, 2023

ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF CUCUMIS SATIVUS FRUIT IN WISTAR RATS

Read More
01 Apr, 2023

DEVELOPMENT AND CHARACTERIZATION OF QUINAPRIL CO-CRYSTALS USING NEUTRACEUTICALS AS CO-FORMERS

Read More
24 Jan, 2023

FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF VENLAFAXINE HCl

Read More
Impact Factor
8.01 (Year 2024)
UGC Approved
Journal no 47859

Join Our IPN

IJIRT Partner Network

Submit your research paper and those of your network (friends, colleagues, or peers) through your IPN account, and receive 800 INR for each paper that gets published.

Join Now

Latest Publication

Archive

View More

Recent Conferences

NCSEM 2024

National Conference on Sustainable Engineering and Management - 2024 Last Date: 15th March 2024

Submit inquiry