FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF VENLAFAXINE HCl

Botla Manohar; Pranay Renukuntla; Daniel Kothapally

FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF VENLAFAXINE HCl

Authors: Botla Manohar, Pranay Renukuntla, Daniel Kothapally

Unique Paper ID: 158123
Volume: 9
Issue: 8
PageNo: 742-746

Keywords: Venlafaxine HCl HPMC sustained release and direct compression

Abstract:
The sustained release tablets of venlafaxine HCl were prepared by direct compression method using release retarding ability of different grades of HPMC polymers (E4M, E15LV & E50LV) and eudrgit L 100 to extend the release of drug over 24hrs period and thereby improve its bioavailability. The developed tablets were evaluated for pre-compression and post-compression parameters. The results of all formulations were found within the pharmacopeial limits. The optimized formulation (F7) with HPMC E50LV showed the maximum percentage of drug release for 24 hrs was 99.76%. The results indicated that at higher viscosity grades of polymer concentrations drug release was retarded greatly were observed. The drug release was showed by higuchi model followed by zero order release.

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Cite This Article

ISSN: 2349-6002
Volume: 9
Issue: 8
PageNo: 742-746

FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF VENLAFAXINE HCl

Available:https://ijirt.org/Article?manuscript=158123

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Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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