Formulation development, in vitro and in vivo studies of eprosartan mesylate loaded solid lipid nanoparticles for improved bioavailability

Cheekati Reshma; PASHAM VENKANNA

Formulation development, in vitro and in vivo studies of eprosartan mesylate loaded solid lipid nanoparticles for improved bioavailability

Authors: Cheekati Reshma, PASHAM VENKANNA

Unique Paper ID: 163204
Volume: 10
Issue: 11
PageNo: 812-817

Keywords: Bioavailability solid lipid nanoparticles homogenization and eprosartan mesylate

Abstract:
Eprosartan mesylate (EM) is an angiotensin receptor blocker (ARB) used to treat hypertension. It has an oral bioavailability of 13%. The work intends to evolve eprosartan mesylate of solid lipid nanoparticles (EM-SLNs) to enhance bioavailability. EM-SLNs were developed using hot homogenization followed by ultrasonication by using lipids dynasan 118, dynasan 116, and dynasan 114. The optimized formulation EM-SLNs (F7) showed the particle size is 151.3 nm, poly disperse index (PDI) shows 0.210 and zeta potential (ZP) values were -31.74mV, which indicated the stability of developed EM-SLNs. The entrapment efficiency (EE) was found to be 85.10%. EM-SLNs were established as likely spherical with a lustrous exterior, as making do with scanning electron microscope (SEM). Relative bioavailability of the optimized EM-SLNs (F7) was increased by 1.84 times, differentiated with the coarse suspension of pure drug.

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Cite This Article

ISSN: 2349-6002
Volume: 10
Issue: 11
PageNo: 812-817

Formulation development, in vitro and in vivo studies of eprosartan mesylate loaded solid lipid nanoparticles for improved bioavailability

Available:https://ijirt.org/Article?manuscript=163204

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Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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