ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF CUCUMIS SATIVUS FRUIT IN WISTAR RATS

GADDAM SUSHMA

ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF CUCUMIS SATIVUS FRUIT IN WISTAR RATS

Authors: GADDAM SUSHMA

Unique Paper ID: 158992
Volume: 9
Issue: 11
PageNo: 108-112

Keywords: Cucumis sativus Antiurolithiatic activity Allopurinol and Ethylene glycol (0.75 % v/v)

Abstract:
The present study explores the antiurolithiatic activity of an ethanolic extract of the Cucumis Sativus (CS) fruit in Wistar rats. Ethylene glycol (0.75% v/v) induced calculi in Wistar rats. They have assessed various parameters like biochemical estimations of serum, urine, and kidney tissue homogenate and histopathological studies of a kidney. The treatment with doses of 200 mg/kg and 400 mg/kg of ethanolic extract of CS exerts dose-dependent anti-urolithic activity. A significant reduction in the deposition of kidney stone-forming constituents like calcium, oxalate, and phosphate was found in the kidneys. The Wistar ratâ€™s kidney sections showed the presence of crystals, dilatation of tubules tubulorrhexis, and the epithelial recovered.

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Cite This Article

ISSN: 2349-6002
Volume: 9
Issue: 11
PageNo: 108-112

ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF CUCUMIS SATIVUS FRUIT IN WISTAR RATS

Available:https://ijirt.org/Article?manuscript=158992

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UGC Approved
Journal no 47859

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