• ISSN: 2349-6002
  • UGC Approved Journal No 47859
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DEVELOPMENT AND CHARACTERIZATION OF QUINAPRIL CO-CRYSTALS USING NEUTRACEUTICALS AS CO-FORMERS

  • Unique Paper ID: 158977
  • Volume: 9
  • Issue: 11
  • PageNo: 97-101
  • Abstract:
  • The co-crystals of quinapril were developed by solvent evaporation method and using nutraceuticals as co-formers such as quercetin, nicotinic acid, curcumin, and caffeine in 1:2 equimolar ratio and observed effect on drug release pattern. The developed co-crystals were tested in pre and post-compression parameters. All formulation findings have been determined to be within pharmacopeial limits. The most significant percentage of drug release for 2 hrs was 99.84% in the optimized formulation (F1) compared with the marketed product (Accupril). The SEM studies showed that optimized formulation (F1) good uniformity as well as crystalline nature. The Higuchi model offers an R2 value of 0.983, indicating that the drug release was followed by non-fickian diffusion.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 9
  • Issue: 11
  • PageNo: 97-101

DEVELOPMENT AND CHARACTERIZATION OF QUINAPRIL CO-CRYSTALS USING NEUTRACEUTICALS AS CO-FORMERS

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